• 10 Best Dog Flea and Tick Medicines in 2022 (Simparica, Sentinel, and More) 1
  • 10 Best Dog Flea and Tick Medicines in 2022 (Simparica, Sentinel, and More) 2
  • 10 Best Dog Flea and Tick Medicines in 2022 (Simparica, Sentinel, and More) 3
  • 10 Best Dog Flea and Tick Medicines in 2022 (Simparica, Sentinel, and More) 4
  • 10 Best Dog Flea and Tick Medicines in 2022 (Simparica, Sentinel, and More) 5

10 Best Dog Flea and Tick Medicines in 2022 (Simparica, Sentinel, and More)

Dogs can bring a lot of joy to our lives, but without flea and tick medicines, they are at risk of developing fatal diseases. Dog and flea tick medicines can be topical or oral. Many require a prescription from your vet, but some can be found over the counter. 


If you are a new dog owner and need a starting point, our 10 best list will give you a few ideas in addition to your vet's advice. We found that Simparica Trio chewable tablets offered well-rounded protection against fleas, ticks, and other internal parasites. Our buying guide will discuss the pros and cons of oral and topical medications, as well as when to be cautious about certain flea and tick remedies. Keep reading to learn more!

Featured in this article

mybest US Editors
  • Last updated: 05-05-2022
Table of Contents

Why Does My Dog Need Flea and Tick Medicine?

Why Does My Dog Need Flea and Tick Medicine?

Fleas and ticks can live year-round, especially as winters are becoming warmer and shorter in northern climates. Dogs are potentially exposed to fleas and ticks in backyards, during hikes or outdoor exercise, when getting groomed, or when they are around other canines at daycare or a boarding facility.


Diseases and conditions like anemia, Lyme disease, and Rocky Mountain fever can be caused by fleas and ticks. Dogs can develop fatigue, lameness, stomach problems, and fevers. Sadly, some of these diseases and conditions can turn fatal.


Flea and tick medicine can get rid of existing larvae and adult insects, and prevent them from infesting your dog. If you regularly take your pet to a daycare facility, you will probably be required to show proof you are taking preventative measures against fleas and ticks.

Compare the 10 Best Dog Flea and Tick Medicines

Image
1
Simparica Trio Chewable Tablet for Dogs 1

Simparica Trio

2
Sentinel Flavor Tabs for Dogs 1

Sentinel

3
K9 Advantix II Flea and Tick Spot Treatment 1

K9 Advantix II

4
Frontline Flea and Tick Treatment 1

Frontline

5
Capstar Fast-Acting Oral Flea Treatment 1

Capstar

6
Sentry Pet Care Fiproguard for Dogs 1

Sentry Pet Care

7
NexGard Soft Chew for Dogs 1

NexGard

8
Bravecto Soft Chews for Dogs 1

Bravecto

9
Comfortis Chewable Tablet for Dogs 1

Comfortis

10
Hartz UltraGuard Pro Reflective Flea & Tick Collar 1

Hartz

Name

Chewable Tablet for Dogs

Flavor Tabs for Dogs

Flea and Tick Spot Treatment

Flea and Tick Treatment

Fast-Acting Oral Flea Treatment

Fiproguard for Dogs

Soft Chew for Dogs

Soft Chews for Dogs

Chewable Tablet for Dogs

UltraGuard Pro Reflective Flea & Tick Collar

Features

Well-Rounded Protection for Your Pup

Prevents New Fleas and Other Parasites

Vet-Recommended Topical Flea and Tick Repellant

Waterproof Flea and Tick Protection for Small Dogs

Fights Existing Infestations in Medium and Large Dogs

Top-Rated Ingredient for Fighting Fleas

FDA-Approved Lyme Disease Prevention

Convenient Dosage Schedule for Small and Medium Dogs

Treat and Prevent Fleas in Small Dogs

Reflective Flea and Tick Collar

Price$158.02$59.99$67.98$36.99$28.45$21.78$62.99$59.49$101.99$5.77
TypeOralOralTopicalTopicalOralTopicalOralOralOralCollar
Prescription or OTCPrescriptionPrescriptionOTCOTCOTCOTCPrescriptionPrescriptionPrescriptionOTC
Dosage intervalMonthlyMonthlyMonthlyMonthlyAs needed (1 dose max per day)MonthlyMonthlyEvery 3 monthsMonthly7 months
Link

10 Best Dog Flea and Tick Medicines

When you choose a flea and tick medicine for your pup, first check with your vet for recommendations. A vet is the best source of suggestions for what medicines will work for your dog. Beyond that, you'll want to decide whether to use oral or topical prevention. 

1

Simparica TrioChewable Tablet for Dogs

6 tablets

$158.02

TypeOral
Prescription or OTCPrescription
Dosage intervalMonthly
2

SentinelFlavor Tabs for Dogs

6 tablets

$59.99

TypeOral
Prescription or OTCPrescription
Dosage intervalMonthly
3

K9 Advantix IIFlea and Tick Spot Treatment

6 doses

$67.98

TypeTopical
Prescription or OTCOTC
Dosage intervalMonthly
4

FrontlineFlea and Tick Treatment

3 doses

$36.99

TypeTopical
Prescription or OTCOTC
Dosage intervalMonthly
5

CapstarFast-Acting Oral Flea Treatment

6 tablets

$28.45

TypeOral
Prescription or OTCOTC
Dosage intervalAs needed (1 dose max per day)
6

Sentry Pet CareFiproguard for Dogs

6 doses

$21.78

TypeTopical
Prescription or OTCOTC
Dosage intervalMonthly
7

NexGardSoft Chew for Dogs

3 doses

$62.99

TypeOral
Prescription or OTCPrescription
Dosage intervalMonthly
8

BravectoSoft Chews for Dogs

1 dose

$59.49

TypeOral
Prescription or OTCPrescription
Dosage intervalEvery 3 months
9

ComfortisChewable Tablet for Dogs

6 doses

$101.99

TypeOral
Prescription or OTCPrescription
Dosage intervalMonthly
10

HartzUltraGuard Pro Reflective Flea & Tick Collar

$5.77

TypeCollar
Prescription or OTCOTC
Dosage interval7 months

How to Choose a Dog Flea and Tick Medicine - Buying Guide

When choosing flea and tick medicine for your dog, you should first consult with your vet about your options and pet's health history. You'll also want to factor in your tolerance and commitment to giving oral medication on a regular schedule. 


Topical options can include conventional and natural remedies, but you should exercise caution when considering natural solutions.

First Off, Ask Your Vet for Guidance

First Off, Ask Your Vet for Guidance

It's best to start with your dog's vet for recommendations on which medicines to use. They will know the latest prescription and over-the-counter treatments that are the most effective for treating and preventing fleas and ticks.


Your vet will be able to provide guidance based on your dog's weight, age, and any other known medical conditions. This includes a history of seizures or a sensitive stomach. For instance, some medicines are safe to use on puppies as young as four weeks. Others are only safe for older dogs.


Your vet will also know what types of ticks and tick-borne illnesses are most common for your geographic region, including what times of the year the insects are most active.

First Off, Ask Your Vet for Guidance

In some cases, using both an oral and topical solution may offer better protection. This might be your case if you live in an area with high tick and flea populations or your dog is regularly exposed to the woods and areas with tall grass or vegetation.


From your vet, you will get guidance on whether you should use preventative medications all year. Although it's becoming less common for vets to advise anything besides year-round protection, there may be some exceptions. These are often based on your dog's activities and potential exposure, as well as your geographic area.

Decide Between Oral and Topical Medications

Decide Between Oral and Topical Medications

Oral medications are more likely to require a prescription from your vet, while topical medications can often be purchased over-the-counter. Pills or chewable medications are usually taken once a month with food and are absorbed systemically. These medicines typically combat heartworm, internal parasites such as hookworms, fleas, and ticks. 


Oral medicines can be a good choice if you want to prevent several different types of parasites at once. They are also good for dogs that tolerate systemic treatments when taken with food. Prescription oral medications can be purchased from your vet's office or online store or through online retailers like Chewy, which require proof of a prescription.

Decide Between Oral and Topical Medications

Topical medicines are applied directly to your dog's skin once a month, usually between the shoulder blades. The medicine gets absorbed into the skin and works by repelling fleas and ticks. These medicines can be better for dogs with sensitive stomachs or those that have a history of neurological conditions like seizures.


A flea and tick collar is an additional topical option for owners that struggle to remember giving medication every month. These collars can last for six to eight months. Some also include reflective materials for outdoor safety at night or in the early morning.

Be Cautious About Natural Remedies

Be Cautious About Natural Remedies

Some owners may prefer to use flea shampoos or natural sprays due to concerns about the chemicals in flea and tick medicines. Households with pregnant women or small children may be especially concerned about the potentially toxic effects of chemicals such as fipronil and metaflumizone.


Vets don't usually recommend the use of natural remedies, as they are not evaluated and monitored like conventional products for effectiveness and safety. Check with your vet first about any natural product you would like to use.


Some natural products can prevent new fleas and ticks from infesting your dog when applied daily, but are not good for getting rid of an active infestation. Be aware that natural remedies may contain essential oils that can harm other pets, such as cats.

Looking for More Dog Care Tips? Check Out These Suggestions!

Sometimes welcoming a fur baby into your family is like having another kid. Here are some other ways you can give your dog the best!

Author: Helen Akers


  • Follow us on Facebook and Instagram for more mybest recommendations! For questions or comments, leave us feedback via a Google Form on our Contact Us page.

Related Articles

  • 10 Best Cat Brushes in 2022 (Cleanhouse Pets, FURminator, and More)
    10 Best Cat Brushes in 2022 (Cleanhouse Pets, FURminator, and More)
    Any cat lover will know—there’s nothing like the feel of silky, glowing, warm, healthy fur beneath the fingers. So get a good brush. It’ll make sure your cat doesn’t get squeamish during grooming sessions and cut down on random hair lying around the house.Pet stores have an extensive list of hairbrushes for your feline companion: short hair brushes, long hair brushes, flea and tick removal brushes, and shedding brushes, to name a few. But picking the right one can be difficult. Read through for advice on how to find the best one, plus a top 10 list, including our favorite GoPets' Dematting Comb, to get you started on your search!
    Pets
  • 10 Best Natural Bones for Dogs in 2022 (Raw Paws Pet Food, K9 Connoisseur, and More)
    10 Best Natural Bones for Dogs in 2022 (Raw Paws Pet Food, K9 Connoisseur, and More)
    When you think of dogs, one of the first images that comes to mind is a dog with a bone. Natural, raw bones have been an essential part of canines’ diets throughout their history of hunting and attacking prey. Believe it or not, today’s canine pets share the same genetic features as their ancestors. Feeding your dog natural bones is a great way to supplement their diet, keep their teeth clean, and provide hours of entertainment.We did the research and put together a list of the top 10 best natural bones for your canine companion. Chicken feet might seem strange at first, but they're full of important nutrients that help promote joint health. And their small size makes them the perfect snack! Keep reading to see the rest of our picks. If you have questions about buying natural bones for your dog, our buying guide should have the answers you seek.
    Pets
  • 9 Best Reptile Heating Pads in 2022 (Zoo Med, iPower, and More)
    9 Best Reptile Heating Pads in 2022 (Zoo Med, iPower, and More)
    Reptiles and other cold-blooded animals can be unique and interesting pets to keep, but they also require some special considerations that a dog or guinea pig wouldn’t. The most important consideration is probably temperature. Unlike warm-blooded animals, reptiles and amphibians need outside heat sources.One of the safest and least obstructive types of heaters you can get is a reptile heating pad, a thin pad that heats a portion of your tank. Our favorite is Zoo Med's ReptiTherm Under Tank Heater. This sturdy, powerful heating pad is strong enough to moderate the ambient temperature of your pet's tank. Read on to compare other reptile heating pads from our curated list!
    Pets
  • 10 Best Cat Trees in 2022 (New Cat Condos, PetPals, and More)
    10 Best Cat Trees in 2022 (New Cat Condos, PetPals, and More)
    Cat trees are a necessary item for many of our feline friends, letting them satisfy their desire to climb. Cat trees also help with other necessities, like having a cozy, safe place to sleep or an appropriate spot to scratch. However, it can be difficult to find a cat condo that's suitable for your cat's needs, safe, and durable! We’ve researched cat trees to find the best options that combine feline friendliness with functional design details. We've carefully selected 10 options to suit a variety of needs, whether you want a cozy tree for an elderly cat or an elaborate tree perfect for energetic kitties. Our favorite is the Multi-Level Cat Tree from Feandrea. It has plenty of room for several cats and comes with a safety strap for stability. Keep reading to see the rest of our picks, and check out our buying guide for all the information you need to make a confident choice.
    Pets
  • 10 Best Dry Dog Foods in 2022 (Blue Buffalo, Diamond Naturals, and More)
    10 Best Dry Dog Foods in 2022 (Blue Buffalo, Diamond Naturals, and More)
    Organic, limited-ingredient, grain-free, freeze-dried, flax-free, and a whole lot of other dry dog food options are available on the market today. But is there really a difference between all these options, and will your pooch know what it is? Well, the answer is yes - all dog foods are not created equal. While your furry friend may be willing to wolf down anything you put in his bowl, his health will certainly be impacted by the quality of dog food you choose. Good quality dog food means better health and a longer life for your dog. Dry dog food is typically made by combining raw ingredients to make a formula that is then made into the bite-sized pieces we commonly refer to as kibble. Dry dog food is convenient, has a long shelf life and offers a host of health benefits including improving your dog’s dental health. We've searched online to find the best dry dog foods and created a buying guide to help you choose the right one for you!
    Pets
  • 10 Best Fish Tanks in 2022 (Marina, Tetra, and More)
    10 Best Fish Tanks in 2022 (Marina, Tetra, and More)
    There are few things more beautiful than an immaculately aquascaped aquarium. But choosing a fish tank is a difficult task, especially for beginners. Even experienced fishkeepers can get overwhelmed with the variety of tanks, filters, lights, and accessories, not to mention the vast amount of misinformation put out by sellers who sacrifice a pet fish's health for money!We've searched Amazon and done a lot of research to help you wade through all the information and make a smart choice. Our first-place tank was Fluval's Flex Freshwater Aquarium Kit because of its built-in filtration and outstanding remote-controlled LED light and color settings. Whether you've had fish tanks before or are just starting out, you'll find our top 10 list and buying guide full of helpful information.
    Pets
  • 10 Best Pet Odor Eliminator Candles in 2022 (Fresh Wave and More)
    10 Best Pet Odor Eliminator Candles in 2022 (Fresh Wave and More)
    As pet owners, we might not realize the "I have a pet" scent that coats the house. It's really there: the mishaps on the carpet or the sofa that didn't fully dry, some fur residue here and there, and if you have cats, the litter box! As much as we love our fur babies, that odor has got to go - which brings us to the topic of candles especially designed to absorb all the scents and deodorize the house. We've picked out the most effective pet odor-eliminating candles you can buy online. Our grand prize went to One Fur All's Pet House Candle, which boasts an all-natural formula and is safe for both you and your pet. We've also included a buying guide to help you choose.
    Pets
  • 10 Best Healthy Dog Treats in 2022 (Jack & Pup, Blue Buffalo, and More)
    10 Best Healthy Dog Treats in 2022 (Jack & Pup, Blue Buffalo, and More)
    It’s hard to say no when your dogs are giving you the puppy eyes at the table. But to show their dogs love and care, many people buy dog treats instead of giving them human food. However, dog treats can be bad for your dog because they can contain a lot of additives that can cause digestive problems, obesity, diabetes, kidney disease, and more.Since there are so many dog treats on the market, it may be difficult to know which to go for. That's why we've provided you with information on what you need to look at when buying dog treats in our buying guide below. We've also picked out the 10 best healthy treats that are safe for your dog to consume!
    Pets
  • 10 Best Pet Wipes for Cats in 2022 (Burt's Bees, Glandex, and More)
    10 Best Pet Wipes for Cats in 2022 (Burt's Bees, Glandex, and More)
    Most, if not all, cat parents know that their furry babies don't like having a bath. Cats do great work in keeping themselves clean. However, there are cases that they miss certain spots of dirt or can't lick themselves due to old age. In situations like these, it's beneficial to have some cat wipes nearby! Cat wipes not only keep your kitties clean and fresh but can also be used for skin rashes, ticks, and much more. We've searched for the best variety of cat wipes you can use on your felines. Burt's Bees' Natural Dander Reducing Wipes was our favorite for its all-natural ingredients and dander-reducing benefits. Take a look at the other products we've included in our top 10 list. A detailed buying guide is also included in this article to give you more insight into your purchase.
    Pets
  • 10 Best Flea Combs for Dogs in 2022 (Safari, Hartz, and More)
    10 Best Flea Combs for Dogs in 2022 (Safari, Hartz, and More)
    Is your dog showing signs of fleas, such as scratching and hair loss? Dog flea combs can help you remove them from your pet's fur. Although flea combs don't prevent infestations, they are a way to help you rid your pet of them at home. Using one requires a certain technique, but it can be a great way to strengthen your relationship with your dog.That's why we created this top 10 list of dog flea combs for inspiration on selecting a comb. We chose Safari's Dog Flea Comb as our number one pick because of its design and suitability for multiple breeds. Also, take a look at our buying guide to see what factors to consider when selecting a flea comb. 
    Pets
  • Popular Articles

  • 10 Best Cat Brushes in 2022 (Cleanhouse Pets, FURminator, and More)
    10 Best Cat Brushes in 2022 (Cleanhouse Pets, FURminator, and More)
    Any cat lover will know—there’s nothing like the feel of silky, glowing, warm, healthy fur beneath the fingers. So get a good brush. It’ll make sure your cat doesn’t get squeamish during grooming sessions and cut down on random hair lying around the house.Pet stores have an extensive list of hairbrushes for your feline companion: short hair brushes, long hair brushes, flea and tick removal brushes, and shedding brushes, to name a few. But picking the right one can be difficult. Read through for advice on how to find the best one, plus a top 10 list, including our favorite GoPets' Dematting Comb, to get you started on your search!
    Pets
  • 10 Best Cat Litters in 2022 (Purina, Arm & Hammer, and More)
    10 Best Cat Litters in 2022 (Purina, Arm & Hammer, and More)
    Though you may have a rough idea of what kind of litter you want, you have to make sure that you aren't forgetting your cat's needs. He or she can be sensitive to odors, have soft paws that can get hurt by rough litter, or have allergies to certain materials. You'll want to go for something as safe as possible for your little friend.Here, we’ve compiled some questions to go through with your cat the next time the litter box runs empty. We’ve also categorized common types of cat litter and summarized their characteristics. And we wrote up a list of litter we’d recommend, with World's Best Cat Litter at the top. So all you need to do is consider the unique situation and tastes of you and your cat.
    Pets
  • 10 Best Natural Bones for Dogs in 2022 (Raw Paws Pet Food, K9 Connoisseur, and More)
    10 Best Natural Bones for Dogs in 2022 (Raw Paws Pet Food, K9 Connoisseur, and More)
    When you think of dogs, one of the first images that comes to mind is a dog with a bone. Natural, raw bones have been an essential part of canines’ diets throughout their history of hunting and attacking prey. Believe it or not, today’s canine pets share the same genetic features as their ancestors. Feeding your dog natural bones is a great way to supplement their diet, keep their teeth clean, and provide hours of entertainment.We did the research and put together a list of the top 10 best natural bones for your canine companion. Chicken feet might seem strange at first, but they're full of important nutrients that help promote joint health. And their small size makes them the perfect snack! Keep reading to see the rest of our picks. If you have questions about buying natural bones for your dog, our buying guide should have the answers you seek.
    Pets
  • 7 Best Axolotl Foods in 2022 (Hikari, Uncle Jim's Worm Farm, and More)
    7 Best Axolotl Foods in 2022 (Hikari, Uncle Jim's Worm Farm, and More)
    If it's your first time owning the exquisite axolotl, you're probably wondering what these walking fishes eat. Do you go for flakes? Or maybe pellets? Axolotls are amphibians that mostly eat worms and small insects in the wild, but they primarily consume food in pellet or frozen forms in captivity. We've researched the best axolotl food available today that caters to all life stages of your new pet. After thorough research, we picked Invert Aquatics' Soft Pellets for Axolotls as our top favorite for its nutritious and moisture-rich sinking pellets. Read on to see six other great options we've included in our list. You'll also see a handy buying guide that will help you learn more about your axolotl and what kind of food is best for them!
    Pets
  • 10 Best Betta Fish Foods in 2022 (Tetra, Hikari, and More)
    10 Best Betta Fish Foods in 2022 (Tetra, Hikari, and More)
    Are you a first-time betta fish parent or looking for new food to feed your colorful fish? You've come to the right place. Betta fishes are carnivores and need a diet high in protein and fat. This article will tackle the best betta fish food in different types: pellets, flakes, and freeze-dried food. We've gone ahead and researched the best betta fish food based on its nutrition and type. Right away, Tetra's BettaMin's pellets took the spot in first place for its nutritious ingredients and ideal size suitable for bettas of all ages. Take a look at the other nine excellent betta fish food we've handpicked, and read until the end to learn some helpful buying tips in our handy buying guide! 
    Pets
  • 9 Best Tried and True Japanese Dog Nail Clippers in 2022 (Petio, Lavuky, and More)
    9 Best Tried and True Japanese Dog Nail Clippers in 2022 (Petio, Lavuky, and More)
    Our editors searched Japanese e-commerce sites such as Amazon, Rakuten, and Kakaku.com for the best Japanese dog nail clippers available online. We then picked out the most popular products and tested them for the following:Pet comfort Ease of cuttingWe consulted with an expert on pet products and dog training to test the clippers. We also discussed the pros and cons of electric and standard cutters and considered how they affect pet comfort. Sharpness and grip comfort were also taken into consideration in our selection. We then compiled everything we learned into a buying guide to help you find the best Japanese dog nail clippers available online.
    Pets
  • 10 Best Cat Trees in 2022 (New Cat Condos, PetPals, and More)
    10 Best Cat Trees in 2022 (New Cat Condos, PetPals, and More)
    Cat trees are a necessary item for many of our feline friends, letting them satisfy their desire to climb. Cat trees also help with other necessities, like having a cozy, safe place to sleep or an appropriate spot to scratch. However, it can be difficult to find a cat condo that's suitable for your cat's needs, safe, and durable! We’ve researched cat trees to find the best options that combine feline friendliness with functional design details. We've carefully selected 10 options to suit a variety of needs, whether you want a cozy tree for an elderly cat or an elaborate tree perfect for energetic kitties. Our favorite is the Multi-Level Cat Tree from Feandrea. It has plenty of room for several cats and comes with a safety strap for stability. Keep reading to see the rest of our picks, and check out our buying guide for all the information you need to make a confident choice.
    Pets
  • Popular Expert Picks

    Search by Category