• 10 Best Eye Drops for Dry Eyes in 2022 (TheraTears, Visine, and More) 1
  • 10 Best Eye Drops for Dry Eyes in 2022 (TheraTears, Visine, and More) 2
  • 10 Best Eye Drops for Dry Eyes in 2022 (TheraTears, Visine, and More) 3
  • 10 Best Eye Drops for Dry Eyes in 2022 (TheraTears, Visine, and More) 4
  • 10 Best Eye Drops for Dry Eyes in 2022 (TheraTears, Visine, and More) 5

10 Best Eye Drops for Dry Eyes in 2022 (TheraTears, Visine, and More)

Do you suffer from dry eyes? Dry eye syndrome is a condition that occurs when the tear glands don't produce enough tears or when the tears aren't enough to keep your eyes lubricated. It can cause eye pain, redness, blurry vision, or itching. Ouch! It's up to an ophthalmologist to make a diagnosis of dry eye syndrome, but eye drops can help give you some relief from both chronic or temporary dryness.


So, we found the best over-the-counter eye drops to relieve dry eye symptoms. Our top choice is TheraTears' Dry Eye Therapy. These drops were created by an ophthalmologist and are recommended by doctors for long-lasting relief. You can find the rest of our recommendations on our top 10 list! Plus, you can scroll down to our buying guide to know what points to consider before you select a product. 

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mybest US Editors
  • Last updated: 08-26-2022
Table of Contents

How to Choose Eye Drops for Dry Eyes – Buying Guide

Regardless of what symptoms you have, you need to consult a doctor to ensure you have dry eye syndrome. If you feel you have dry eyes, an ophthalmologist will be able to make the diagnosis and prescribe you the best eye drops to combat the symptoms. 


But if you've already been diagnosed and are looking for over-the-counter (or "OTC" eye drops) as per your doctor's advice, one of our top 10 products might suit you. Our buying guide will help you understand what basics you need to know before going for OTC eye drops for dry eyes. 

Know the Types of Eye Drops for Dry Eyes

Pharmacies have a range of eye drops to treat dry eyes. Doctors recommend these drops based on the severity of your symptoms. Eye drops that work for mild to moderate symptoms might not be suitable for someone with chronic dry eye syndrome.  

Get Prescription Eye Drops for Dry Eyes Due to Inflammation

Get Prescription Eye Drops for Dry Eyes Due to Inflammation

Sometimes chronic dry eyes can result from an inflammation caused by conditions like dry eye (or keratoconjunctivitis sicca). It means dryness of the conjunctiva, the thin membrane that covers the eyelids and the white of the eye, and cornea, the clear layer in front of the eye. 


Doctors prescribe eye drops like Cyclosporine for such conditions. They can increase your eyes' capability to produce tears. These drops can have a different composition than OTC drops. Besides treating dryness, prescription eye drops might contain ingredients to reduce inflammation and redness. 

Over-the-Counter Artificial Tears are the Most Common

Over-the-Counter Artificial Tears are the Most Common

Artificial tears are the most common types of eye drops for dry eye syndrome. They are formulated with one or more humectants that can retain the eyes' outer surface moisture and reduce tear evaporation.


Besides the lubricants needed to keep your eyes moist, artificial tears also contain electrolytes like potassium and sodium that help heal the strain at the eyes' surface.

But Artificial Tears Might Not Work for Severe Dry Eye Syndrome

But Artificial Tears Might Not Work for Severe Dry Eye Syndrome

Artificial tears or prescription eye drops might not work for those with severe dry eye syndrome. You might need a lubricant gel, like Celluvisc, or an ointment like Lacri-Lube that's thicker and can remain longer in the eyes. They are suitable for overnight use as they tend to blur the vision for a while.


The thicker the composition, the longer it stays in your eyes and blurs your vision. But do not worry. Your eyes will be blurry only temporarily while the gel or ointment stays in your eyes.


Tear inserts are rod-shaped translucent and sterile inserts for the eye. They are water-soluble and slow-release and used when artificial tears aren't sufficient to treat dry eye syndrome. They contain a water-soluble cellulose like hydroxypropyl cellulose that thickens and stabilizes the fluid layer and provide sufficient lubrication.

Choose Between Eyedrops With and Without Preservatives

Choose Between Eyedrops With and Without Preservatives

Eye drops with preservatives discourage and inhibit the growth of bacteria in the bottle once it’s opened. They are ideal for those with mild dry eye syndrome and are found in multi-dose bottles. The presence of preservatives or chemicals can irritate the eyes of those with moderate to severe dry eyes. 


Eye drops with few or no preservatives are ideal for frequent use and those who wear contact lenses. These drops are suitable for moderate to severe dry eye syndrome. They are safe to use three to four times a day. The label will often say whether they’re safe for use with contact lenses, so read the label carefully.


Sometimes dry eyes can be caused by diminished layers of oil inside the eyes. In that case, your doctor might prescribe an eye drop with lubricant oil, such as castor oil, as the inactive ingredient.  

Get the Right Ingredients for Your Specific Concerns

Get the Right Ingredients for Your Specific Concerns

Lubricant eye drops contain an ophthalmic demulcent (water-soluble polymer) or lubricants like glycerin, carboxymethylcellulose, or polyethylene glycol as the primary or active ingredient. They can improve the lubricant properties of the eye drops and keep your eyes moist for a long time


Emollients like mineral oils and paraffin are often included to soften the tissues and prevent the tear film from drying up. They can replace or thicken the tear film's compromised layer, reduce the tear evaporation rate, and increase the tear breakup time.

Get the Right Ingredients for Your Specific Concerns

Electrolytes like potassium, bicarbonate, chloride, and sodium are other essential ingredients. Low levels of electrolytes can reduce tear breakup time and eventually lead to evaporative dry eye, which is the most common type of dry eye syndrome.


Some eye drops contain sodium chloride or salt. It can reduce swelling and redness. Just a quick search about the ingredients will give information about their functions in treating dry eyes!

Everyone Should See a Doctor First, but Especially People With These Conditions

Everyone Should See a Doctor First, but Especially People With These Conditions

Some eye drops are sold with the intent to reduce the redness of the eyes. They aren't going to be effective in treating dry eye syndrome, because they aren't meant for prolonged use. Anyone with an eye condition, such as glaucoma and cataracts, should only use prescription eye drops to treat dry eyes.


If you're pregnant, some eye drops cannot be used, so you should consult a doctor and get their recommendation. Drying of the eyes is quite common during pregnancy. Your doctor will be able to prescribe the safest possible artificial tears or equivalent eye drops for you.


Regardless of your health, you should always consult an ophthalmologist before buying over-the-counter dry eye drops. 

10 Best Eye Drops for Dry Eyes

Our top 10 eye drops for dry eyes were chosen after careful research about each product and analyzing customer reviews. We found that because everyone's eye condition is different, there is always a chance that even a product with great reviews may cause irritation or discomfort for you.


Note: This article isn't intended to diagnose dry eye syndrome, so it's important to speak with an ophthalmologist before using any of the following over-the-counter eye drops. And discontinue use if you have a negative reaction!

Image
1
TheraTears Dry Eye Therapy 1

TheraTears

2
Refresh Tears Lubricant Eye Drops 1

Refresh

3
Systane  Ultra Lubricant Eye Drops 1

Systane

4
OCuSOFT Retaine MGD 1

OCuSOFT

5
Refresh Optive Mega-3 1

Refresh

6
Blink Tears 1

Blink

7
Visine  All Day Comfort Dry Eye Relief 1

Visine

8
Refresh  Optive 1

Refresh

9
Blink  Contacts 1

Blink

10
Similasan  Dry Eye Relief 1

Similasan

Name

Dry Eye Therapy

Tears Lubricant Eye Drops

Ultra Lubricant Eye Drops

Retaine MGD

Optive Mega-3

Tears

All Day Comfort Dry Eye Relief

Optive

Contacts

Dry Eye Relief

Features

Doctor-Created Eye Drops for Fast Relief from Dry Eyes

Moisturizing Artificial Tears for Mild to Moderate Dry Eye Syndrome

Ultra-Lubricating Dry Eye Drops for Heavy Computer Users

Mineral Oil-Rich Single-Use Vials for Deeper Hydration

Preservative-Free Vials With Oils to Prevent Evaporation

Long-Lasting Eye Drops With Reduced Blur

Lubricant-Rich Eye Drops to Soothe Dry and Gritty Eyes

Lubricating Vials for All Day Comfort from Dry Eyes

Moisturizing Formula for Contact Lens Wearers

Relief from Dry Eye Symptoms With Natural Ingredients

Price$11.99$13.00$26.34$20.52$16.15$11.19$9.81$19.70$11.98$13.96
TypeBottleBottleBottleSingle-use vialsSingle-use vialsBottleBottleSingle-use vialsBottleBottle
Active ingredientsSodium carboxymethylcelluloseCarboxymethylcellulose sodiumPolyethylene glycol, propylene glycolMineral oilCarboxymethylccellulose sodium, glycerin, polysorbatePolyethylene glycolGlycerine, hypromellose polyethylene glycol Carboxymethylcellulose sodium, glycerinSodium hyaluronateBelladona, eyebright plant extract, mercurius sublimatus
Pack of12330 30116021
Amount1 fl. oz. 0.5 fl.oz. each0.33 fl.oz. each0.01 fl.oz. each0.01 fl.oz. each1 fl.oz.0.5 fl.oz.0.01 fl.oz. each0.34 fl.oz. each0.33 fl.oz.
HighlightsDoctor-recommended--Preservative-freePreservative-free, contains flaxseed oil and castor oil--Preservative-freeFor soft and RGP lensesNatural ingredients
Safe for contactsNot specifiedYesNoNot specifiedNot specifiedNoNoNot specifiedYesNot specified
Link
1

TheraTearsDry Eye Therapy

$11.99

TypeBottle
Active ingredientsSodium carboxymethylcellulose
Pack of1
Amount1 fl. oz.
HighlightsDoctor-recommended
Safe for contactsNot specified
2

RefreshTears Lubricant Eye Drops

$13.00

TypeBottle
Active ingredientsCarboxymethylcellulose sodium
Pack of2
Amount0.5 fl.oz. each
Highlights-
Safe for contactsYes
3

Systane Ultra Lubricant Eye Drops

$26.34

TypeBottle
Active ingredientsPolyethylene glycol, propylene glycol
Pack of3
Amount0.33 fl.oz. each
Highlights-
Safe for contactsNo
4

OCuSOFTRetaine MGD

$20.52

TypeSingle-use vials
Active ingredientsMineral oil
Pack of30
Amount0.01 fl.oz. each
HighlightsPreservative-free
Safe for contactsNot specified
5

RefreshOptive Mega-3

$16.15

TypeSingle-use vials
Active ingredientsCarboxymethylccellulose sodium, glycerin, polysorbate
Pack of30
Amount0.01 fl.oz. each
HighlightsPreservative-free, contains flaxseed oil and castor oil
Safe for contactsNot specified
6

BlinkTears

$11.19

TypeBottle
Active ingredientsPolyethylene glycol
Pack of1
Amount1 fl.oz.
Highlights-
Safe for contactsNo
7

Visine All Day Comfort Dry Eye Relief

$9.81

TypeBottle
Active ingredientsGlycerine, hypromellose polyethylene glycol
Pack of1
Amount0.5 fl.oz.
Highlights-
Safe for contactsNo
8

Refresh Optive

$19.70

TypeSingle-use vials
Active ingredientsCarboxymethylcellulose sodium, glycerin
Pack of60
Amount0.01 fl.oz. each
HighlightsPreservative-free
Safe for contactsNot specified
9

Blink Contacts

$11.98

TypeBottle
Active ingredientsSodium hyaluronate
Pack of2
Amount0.34 fl.oz. each
HighlightsFor soft and RGP lenses
Safe for contactsYes
10

Similasan Dry Eye Relief

$13.96

TypeBottle
Active ingredientsBelladona, eyebright plant extract, mercurius sublimatus
Pack of1
Amount0.33 fl.oz.
HighlightsNatural ingredients
Safe for contactsNot specified

Take Care of Your Eyes!

We often take our healthy eyes for granted, until they feel tired and irritated, or worse. Make sure to give your eyes the care they need! Check out these products that can help.

Author: Biji Ravindran


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